This project seeks to understand changes in brain dynamics and behavior of a subject recovering from unconsciousness. In particular, we aim to establish metrics that distinguish reflexive movements from purposeful movements by combining parameters showing that an individual has regained integrative function: cortical activity, motor behavior, and posture. We apply in vivo recordings and statistical learning approaches to characterize these cortico-motor regimens.
Publications:
Objective and graded calibration of recovery of consciousness in experimental models. Calderon DP, Schiff ND.Curr Opin Neurol. 2021 Feb 1;34(1):142-149. doi: 10.1097/WCO.0000000000000895.PMID: 33278146
Robust alternative to the righting reflex to assess arousal in rodents. Gao S, Calderon DP. Sci Rep. 2020 Nov 20;10(1):20280. doi: 10.1038/s41598-020-77162-3.PMID: 33219247 Free PMC article.